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The crash was on I-81 South around mile marker 82.5, PennDOT's Thompson said in a statement at 12:16 p.m.
The interstate is closed at Exit 85 - Route 934/Annville/Ft Indiantown Gap.
"The closure is expected to last a while," Thompson said.
The roadway reopened at 6:18 p.m., a spokesperson told us in an update statement.
There was no word on any injuries, or how the crash happened.
Check back here for updates.
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